FEATURES

FAMILY

DESCRIPTION

Also known as DGKB_HUMAN, DGKB, DAGK2, KIAA0718. Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1, 2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1, 2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity)., Does not associate with membranes but has a diacylglycerol kinase activity.

EXTERNAL LINKS

DGKB

Diacylglycerol kinase beta

DGKB

Molecular Synopsis