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DAGLA (Sn1-specific diacylglycerol lipase alpha)
FEATURES
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FAMILY
DESCRIPTION
Also known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR. Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Also known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR. Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
DAGLA logo

DAGLA

Sn1-specific diacylglycerol lipase alpha

Germline Genetics

Summary of germline evidence for DAGLA and cancer

  • Ensembl Gene ID: ENSG00000134780
  • Ensembl Transcript ID/s: ENST00000257215
  • Entrez Gene ID: 747
  • HGNC Gene Symbol: DAGLA

Genome-wide association studies

DAGLA maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
2728_rs174594 11q12.2 61619829 rs174594-A NR 2E-13 1.134 [1.097-1.172] Colorectal cancer 29471430 https://www.ebi.ac.uk/gwas/search?query=rs174594 - r2>0.3 (11:61322832-61982225) -
787_rs174549 11q12.2 61571382 rs174549-? 0.59 1E-20 1.37 [1.28-1.47] Laryngeal squamous cell carcinoma 25194280 https://www.ebi.ac.uk/gwas/search?query=rs174549 - r2>0.9 (11:61126521-61788062) -
1488_rs174537 11q12.2 61552680 rs174537-G 0.59 9E-21 1.16 [1.12-1.19] Colorectal cancer 24836286 https://www.ebi.ac.uk/gwas/search?query=rs174537 - r2>0.9 (11:61069686-61788062) -
979_rs174537 11q12.2 61552680 rs174537-G 0.59 9E-21 1.16 [1.12-1.19] Colorectal cancer 26965516 https://www.ebi.ac.uk/gwas/search?query=rs174537 - r2>0.9 (11:61069686-61788062) -