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DAGLA (Sn1-specific diacylglycerol lipase alpha)
FEATURES
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FAMILY
DESCRIPTION
Also known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR. Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Also known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR. Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
DAGLA logo

DAGLA

Sn1-specific diacylglycerol lipase alpha

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 147 1.04
NS 0 0 0 153 1.05
carcinoma 0 0 0 552 1.06
haematopoietic_neoplasm 0 0 0 63 1.01
leukaemia 0 0 0 84 1.01
lymphoid_neoplasm 0 0 0 135 1.01
glioma 0 0 0 52 1.00
malignant_melanoma 0 0 0 56 0.99
melanoma 0 0 0 43 0.97
glioblastoma 0 0 0 2 0.97

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 4 2.99 1.34 cancer, carcinoma bladder, urinary_tract
639-V No signal 3 2.41 1.25 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 3 2.50 1.20 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 3 2.20 1.37 glioma brain, central_nervous_system
8305C No signal 4 3.09 1.29 carcinoma thyroid
8505C No signal 4 3.00 1.33 carcinoma thyroid