FEATURES

FAMILY

DESCRIPTION

Also known as LCAP_HUMAN, LNPEP, OTASE. Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Homodimer. Binds tankyrases 1 and 2.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

LNPEP

Leucyl-cystinyl aminopeptidase

ligandability Mutations

LNPEP

Molecular Synopsis