FEATURES

DESCRIPTION

Also known as ATS1_HUMAN, ADAMTS1, KIAA1346, METH1. Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1

ligandability Mutations

ADAMTS1

Molecular Synopsis