FEATURES

FAMILY

DESCRIPTION

Also known as SAE2_HUMAN, UBA2, SAE2, UBLE1B. The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

UBA2

SUMO-activating enzyme subunit 2

ligandability Mutations

UBA2

Molecular Synopsis