FEATURES

DESCRIPTION

Also known as TPSN_MOUSE, Tapbp, Tapa. Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Interacts with TAP1 and is thus a subunit of the TAP complex. Interaction with TAP1 is TAP2 independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, ERp57 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP.

... More

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

Tapbp

Tapasin

ligandability Mutations

Tapbp

Molecular Synopsis