FEATURES

FAMILY

DESCRIPTION

Also known as LGMN_RAT, Lgmn, Prsc1. Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Monomer after autocatalytic processing. Homodimer before autocatalytic removal of the propeptide. May interact with integrins (By similarity).

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EXTERNAL LINKS

Lgmn

Legumain

ligandability Mutations

Lgmn

Molecular Synopsis