SPBP23A10.03c (Succinate dehydrogenase assembly factor 3, mitochondrial)

FEATURES

FAMILY

DESCRIPTION

Also known as SDHF3_SCHPO, SPBP23A10.03c. Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. Interacts with sdh2 within an sdh1-sdh2 subcomplex.

... More

EXTERNAL LINKS

SPBP23A10.03c

Succinate dehydrogenase assembly factor 3, mitochondrial

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

SPBP23A10.03c

Molecular Synopsis