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MDFIC (MyoD family inhibitor domain-containing protein)
FEATURES
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FAMILY
DESCRIPTION
Also known as MDFIC_HUMAN, MDFIC. Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (PubMed:12192039). Interacts with CCNT2 (PubMed:17289077).
Also known as MDFIC_HUMAN, MDFIC. Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the ...
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MDFIC

MyoD family inhibitor domain-containing protein

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.26 1.99 1.79 1.55 0.78 126 2.43 2.06 1.98 1.90 -0.09 -0.19
Bladder (BLCA) 406 2.71 1.97 1.87 1.74 0.89 9 1.88 1.84 1.76 1.73 1.60 0.11
Breast (BRCA) 1067 2.27 1.87 1.77 1.64 0.97 178 2.41 2.12 1.92 1.75 1.30 -0.15
Cervical (CESC) 297 2.15 1.84 1.69 1.50 0.68 10 1.91 1.80 1.75 1.73 1.62 -0.06
Cholangiocarcinoma (CHOL) 36 2.25 2.03 1.92 1.80 0.75 0
Colon (COAD) 443 2.14 1.55 1.38 1.16 0.41 166 2.02 1.74 1.56 1.46 -0.09 -0.18
B-cell lymphoma (DLBC) 42 2.57 2.39 2.21 2.02 1.61 337 2.26 1.83 1.65 1.50 0.39 0.56
Esophageal (ESCA) 142 2.16 1.85 1.70 1.49 0.97 271 2.13 1.89 1.81 1.73 -0.09 -0.11
Glioblastoma (GBM) 160 2.20 1.78 1.63 1.43 0.83 214 1.50 1.05 0.93 0.79 -0.09 0.70
Head and neck (HNSC) 432 2.26 1.88 1.78 1.67 0.97 55 2.13 1.85 1.79 1.73 1.46 -0.01