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TRPM5 (Transient receptor potential cation channel subfamily M member 5)
FEATURES
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FAMILY
DESCRIPTION
Also known as TRPM5_HUMAN, TRPM5, LTRPC5, MTR1. Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Also known as TRPM5_HUMAN, TRPM5, LTRPC5, MTR1. Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated dir ...
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TRPM5

Transient receptor potential cation channel subfamily M member 5

Germline Genetics

Summary of germline evidence for TRPM5 and cancer

  • Ensembl Gene ID: ENSG00000070985
  • Ensembl Transcript ID/s: ENST00000155858
  • Entrez Gene ID: 29850
  • HGNC Gene Symbol: TRPM5

Genome-wide association studies

TRPM5 maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
1322_rs7944004 11p15.5 2311152 rs7944004-T 0.49 2E-10 1.2 [1.13-1.27] Chronic lymphocytic leukemia 23770605 https://www.ebi.ac.uk/gwas/search?query=rs7944004 11:2220000-3060000 r2>0.1 (11:2306634-2427364) -
1529_rs7126629 11p15.5 2228952 rs7126629-C 0.21 2E-8 1.44 [1.31-1.57] Prostate cancer (early onset) 24740154 https://www.ebi.ac.uk/gwas/search?query=rs7126629 11:2220000-3060000 r2>0.1 (11:1808369-2544293) -
1148_rs2651823 11p15.5 2321650 rs2651823-A NR 5E-11 1.18 [1.13-1.25] Chronic lymphocytic leukemia 28165464 https://www.ebi.ac.uk/gwas/search?query=rs2651823 11:2220000-3060000 r2>0.1 (11:2040312-2430304) -
1087_rs2521269 11p15.5 2321095 rs2521269-C 0.458 4E-8 1.1904762 [1.12-1.27] Chronic lymphocytic leukemia 26956414 https://www.ebi.ac.uk/gwas/search?query=rs2521269 11:2220000-3060000 r2>0.2 (11:2306683-2427364) -
1449_rs7127900 11p15.5 2233574 rs7127900-? 0.2 3E-33 1.22 [1.17-1.27] Prostate cancer 19767753 https://www.ebi.ac.uk/gwas/search?query=rs7127900 11:2220000-3060000 r2>0.1 (11:1808369-2544293) -