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AHSP (Alpha-hemoglobin-stabilizing protein)
FEATURES
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FAMILY
DESCRIPTION
Also known as AHSP_HUMAN, AHSP, EDRF, ERAF. Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha(2)beta(2) hemoglobin A.
Also known as AHSP_HUMAN, AHSP, EDRF, ERAF. Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Monomer. Forms a heterod ...
AHSP logo

AHSP

Alpha-hemoglobin-stabilizing protein

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 147 1.01
NS 0 0 0 153 1.03
carcinoma 2 2 2.05 0 548 1.02
haematopoietic_neoplasm 0 0 0 63 0.99
leukaemia 0 0 0 84 1.00
lymphoid_neoplasm 1 0 1 0.43 134 1.05
glioma 1 1 2.03 0 51 0.99
malignant_melanoma 0 0 0 56 1.00
melanoma 0 0 0 43 0.98
glioblastoma 0 0 0 2 1.11

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 2 2.99 0.67 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 3 3.09 0.97 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid