FEATURES

FAMILY

mitochondrial carrier (TC 2.A.29) family

DESCRIPTION

Also known as MFRN1_HUMAN, SLC25A37, MFRN, MSCP. Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). Interacts with ACB10; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC25A37

Mitoferrin-1

SLC25A37

Molecular Synopsis