FEATURES

FAMILY

DESCRIPTION

Also known as KBRS2_HUMAN, NKIRAS2, KBRAS2. Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.

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EXTERNAL LINKS

NKIRAS2

NF-kappa-B inhibitor-interacting Ras-like protein 2

ligandability Mutations

NKIRAS2

Molecular Synopsis