FEATURES

FAMILY

inositol 1,4,5-trisphosphate 5-phosphatase type IV family

DESCRIPTION

Also known as INP5E_HUMAN, INPP5E. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3), phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) and phosphatidylinositol 3, 5-bisphosphate (PtdIns(3, 5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.

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EXTERNAL LINKS

INPP5E

Phosphatidylinositol polyphosphate 5-phosphatase type IV

ligandability Mutations

INPP5E

Molecular Synopsis