FEATURES

FAMILY

DESCRIPTION

Also known as METL5_HUMAN, METTL5. Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665). N6-methylation of adenine(1832) in 18S rRNA is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity). Heterodimer; heterodimerizes with TRMT112.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

METTL5

rRNA N6-adenosine-methyltransferase METTL5

ligandability Mutations

METTL5

Molecular Synopsis