FEATURES

DESCRIPTION

Also known as ARHG4_HUMAN, ARHGEF4, KIAA1112. Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Isoform 3 interacts with RHOA and RAC1, and (via ABR domain) with APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1.

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EXTERNAL LINKS

ARHGEF4

Rho guanine nucleotide exchange factor 4

ligandability Mutations

ARHGEF4

Molecular Synopsis