FEATURES

FAMILY

DESCRIPTION

Also known as SSU72_HUMAN, SSU72. Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Interacts with GTF2B (via C-terminus); this interaction is inhibited by SYMPK (PubMed:15659578, PubMed:29158257). Interacts with RB1 (PubMed:15659578). Interacts with CD226 (PubMed:15659578). Interacts with SYMPK (PubMed:20861839, PubMed:23070812).

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EXTERNAL LINKS

SSU72

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

ligandability Mutations

SSU72

Molecular Synopsis