ilcr-1 (Interleukin cytokine receptor-related protein 1)

FEATURES

DESCRIPTION

Also known as ILCR1_CAEEL, ilcr-1. Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Component of a heterodimeric receptor complex composed of ilcr-1 and ilcr-2. The receptor complex interacts with actl-1 and ilc-17.1 with the interaction being mediated by ilcr-2.

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EXTERNAL LINKS

ilcr-1

Interleukin cytokine receptor-related protein 1

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

ilcr-1

Molecular Synopsis