FEATURES

FAMILY

DESCRIPTION

Also known as BETB_PSEAE, betB. Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid. In P.aeruginosa this reaction is a compulsory step in the assimilation of carbon and nitrogen when bacteria are growing in choline or choline precursors. Can use NADP(+) with similar efficiency to NAD(+), a property that can be used by the bacterium to produce the NADPH needed to combat the oxidative stress imposed by the host defenses. Dimer of dimers.

EXTERNAL LINKS

uniprot
enzyme classification

betB

NAD/NADP-dependent betaine aldehyde dehydrogenase

betB

Molecular Synopsis