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MSL2 (E3 ubiquitin-protein ligase MSL2)
FEATURES
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FAMILY
DESCRIPTION
Also known as MSL2_HUMAN, MSL2, KIAA1585, MSL2L1, RNF184. Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (PubMed:16543150, PubMed:23084835). Forms a MSL heterotetrameric core with MSL1 (PubMed:16543150).
Also known as MSL2_HUMAN, MSL2, KIAA1585, MSL2L1, RNF184. Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), ...
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MSL2

E3 ubiquitin-protein ligase MSL2

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.06 1.82 1.71 1.62 1.45 126 1.83 1.68 1.64 1.61 -0.09 0.06
Bladder (BLCA) 406 2.13 1.85 1.77 1.70 1.31 9 1.84 1.81 1.77 1.68 1.59 -0.00
Breast (BRCA) 1067 2.21 1.90 1.84 1.77 1.43 178 1.94 1.79 1.75 1.71 1.59 0.09
Cervical (CESC) 297 2.26 2.00 1.92 1.81 1.60 10 1.84 1.84 1.76 1.74 1.64 0.16
Cholangiocarcinoma (CHOL) 36 1.99 1.82 1.77 1.67 1.54 0
Colon (COAD) 443 2.16 1.85 1.79 1.72 1.30 166 2.04 1.76 1.72 1.68 -0.09 0.07
B-cell lymphoma (DLBC) 42 2.22 2.01 1.94 1.89 1.76 337 2.71 2.22 2.10 1.97 1.45 -0.16
Esophageal (ESCA) 142 2.18 1.87 1.80 1.73 1.56 271 1.88 1.74 1.70 1.66 -0.09 0.09
Glioblastoma (GBM) 160 1.91 1.71 1.66 1.59 1.38 214 2.34 1.75 1.70 1.66 -0.09 -0.04
Head and neck (HNSC) 432 2.65 1.93 1.83 1.76 1.49 55 1.80 1.77 1.72 1.67 1.60 0.11