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RPAP3 (RNA polymerase II-associated protein 3)
FEATURES
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FAMILY
DESCRIPTION
Also known as RPAP3_HUMAN, RPAP3. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Tightly associated with the RNA polymerase II complex (PubMed:17643375). Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3 (PubMed:20864032). Interacts with PIH1D1 (PubMed:21078300). Interacts with TSC1 and TSC2 (PubMed:28561026). Interacts with PRPF8 and EFTUD2 in a ZNHIT2-dependent manner (PubMed:28561026).
Also known as RPAP3_HUMAN, RPAP3. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Tightly associated with the RNA polymerase II complex (PubMed:17643375). Component of the R2TP complex composed at least ...
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RPAP3

RNA polymerase II-associated protein 3

Germline Genetics

Summary of germline evidence for RPAP3 and cancer

  • Ensembl Gene ID: ENSG00000005175
  • Ensembl Transcript ID/s: ENST00000005386; ENST00000380650; ENST00000432584
  • Entrez Gene ID: 79657
  • HGNC Gene Symbol: RPAP3

Genome-wide association studies

RPAP3 maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
796_rs80130819 12q13.11 48419618 rs80130819-A 0.91 2E-9 1.14 [1.09-1.18] Prostate cancer 25217961 https://www.ebi.ac.uk/gwas/search?query=rs80130819 - r2>0.1 (12:47919738-48918612) -
1350_rs80130819 12q13.11 48419618 rs80130819-A 0.91 4E-8 1.13 [1.08-1.17] Prostate cancer 25217961 https://www.ebi.ac.uk/gwas/search?query=rs80130819 - r2>0.1 (12:47919738-48918612) -