FEATURES

FAMILY

DESCRIPTION

Also known as KDM4C_HUMAN, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780. Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

KDM4C

Lysine-specific demethylase 4C

ligandability Mutations

KDM4C

Molecular Synopsis