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AICDA (Single-stranded DNA cytosine deaminase)
FEATURES
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FAMILY
DESCRIPTION
Also known as AICDA_HUMAN, AICDA, AID. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA (PubMed:18722174, PubMed:21385873). Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1 (PubMed:16387847). Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H (PubMed:21518874). Interacts with RNF126 (PubMed:23277564). Directly interacts with MCM3AP; this interaction may favor AICDA recruitment to immunoglobulin variable region genes, hence promoting somatic hypermutations (PubMed:20507984).
Also known as AICDA_HUMAN, AICDA, AID. Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal diff ...
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AICDA

Single-stranded DNA cytosine deaminase

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 0.51 -0.72 -0.70 -0.52 -0.02 126 0.03 -0.70 -0.69 -0.47 -0.00 -0.01
Bladder (BLCA) 406 1.92 -0.74 -0.55 -0.36 -0.00 9 -0.75 -0.73 -0.72 -0.69 -0.28 0.17
Breast (BRCA) 1067 2.52 -0.75 -0.53 -0.31 -0.00 178 0.53 -0.76 -0.48 -0.19 -0.01 -0.05
Cervical (CESC) 297 0.58 -0.73 -0.49 -0.32 -0.00 10 -0.69 -0.49 -0.46 -0.29 -0.00 -0.04
Cholangiocarcinoma (CHOL) 36 1.07 0.12 -0.55 -0.32 -0.01 0
Colon (COAD) 443 1.13 -0.71 -0.66 -0.40 -0.00 166 0.59 -0.71 -0.47 -0.30 -0.02 -0.19
B-cell lymphoma (DLBC) 42 2.61 2.27 1.82 1.22 -0.09 337 1.10 0.26 -0.63 -0.32 -0.00 2.45
Esophageal (ESCA) 142 0.98 -0.81 -0.45 -0.27 -0.00 271 0.34 -0.70 -0.67 -0.41 -0.03 0.22
Glioblastoma (GBM) 160 -0.88 -0.80 -0.62 -0.54 -0.21 214 -0.78 -0.73 -0.72 -0.70 -0.00 0.10
Head and neck (HNSC) 432 1.43 -0.71 -0.48 -0.29 -0.00 55 0.12 -0.72 -0.51 -0.46 -0.04 0.03