QKI logo
QKI (Protein quaking)
FEATURES
Loading...
Loading...
DESCRIPTION
Also known as QKI_CANLF, QKI. RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
Also known as QKI_CANLF, QKI. RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte d ... More
QKI logo

QKI

Protein quaking

Molecular Synopsis