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lktA (Leukotoxin)
FEATURES
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FAMILY
DESCRIPTION
Also known as LKA2A_MANHA, lktA. Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity). This leukotoxin is a major contributor to the pathogenesis of lung injury in bovine pneumonic pasteurellosis. It has also weak hemolytic activity.
Also known as LKA2A_MANHA, lktA. Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the ... More
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lktA

Leukotoxin

Molecular Synopsis