Mapk8ip2 (C-Jun-amino-terminal kinase-interacting protein 2)

FEATURES

FAMILY

DESCRIPTION

Also known as JIP2_MOUSE, Mapk8ip2, Ib2, Jip2. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity). Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13 (By similarity). Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the TPR motif-containing C-terminal of kinesin light chain. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Interacts with DCLK2. Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity. Interacts with TIAM1 and TIAM2 (PubMed:10827199, PubMed:11378392, PubMed:16628014, PubMed:19893486). Interacts with SH3RF2 (By similarity).

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EXTERNAL LINKS

Mapk8ip2

C-Jun-amino-terminal kinase-interacting protein 2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Mapk8ip2

Molecular Synopsis