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Marcksl1 (MARCKS-related protein)
FEATURES
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FAMILY
DESCRIPTION
Also known as MRP_RAT, Marcksl1, Mlp. Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status. Interacts with calmodulin.
Also known as MRP_RAT, Marcksl1, Mlp. Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, incl ... More
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Marcksl1

MARCKS-related protein

Molecular Synopsis