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P/V/C (Protein C')
FEATURES
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FAMILY
DESCRIPTION
Also known as C_SENDA, P/V/C. The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm. They inhibit IFN-gamma induced serine phosphorylation of STAT1. Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma. May also have a role in preventing the cell to enter apoptosis. Modulate regulation of viral transcription and replication. Overexpression inhibits the viral RNA polymerase. The absence of all C', C and Y1 proteins leads to viral delayed growth. Plays an important role in virion particles release. Modulates virion shape. The different isoforms interact (via C-terminus) with unphosphorylated and phosphorylated human STAT1 (via N-terminus), favoring the formation of parallel STAT1 homodimers. The different isoforms do not interact with host STAT2. C protein interacts with L protein; this interaction has an inhibitory effect on viral transcription and replication.
Also known as C_SENDA, P/V/C. The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cyto ... More
P/V/C logo

P/V/C

Protein C'

Molecular Synopsis