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(Disintegrin saxatilin)
FEATURES
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FAMILY
DESCRIPTION
Also known as VM2_GLOHA. Inhibits fibrinogen interaction with platelets by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3). Also inhibits ADP-induced platelet aggregation. Inhibits basic fibroblast growth factor (bFGF)-induced proliferation of human vascular endothelial cell (HUVEC), and vitronectin-induced migration of smooth muscle cells (SMC). It also regulates platelet activation associated with HUVEC migration and invasion, suppresses TNF-alpha-induced ovarian cancer cell proliferation and invasion, and inhibits angiogenesis and tumor progression. Monomer.
Also known as VM2_GLOHA. Inhibits fibrinogen interaction with platelets by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3). Also inhibits ADP-induced platelet aggregation. Inhibits basic fibroblast growth factor (bFGF)-induced proliferation of human vascular endothelial cell (HUVEC), and vitronectin-induced migration of smooth muscle cells (SMC). It als ... More
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Disintegrin saxatilin

Molecular Synopsis