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(Snaclec agkicetin-C subunit alpha)
FEATURES
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FAMILY
DESCRIPTION
Also known as SLCA_DEIAC. Is a potent glycoprotein Ibalpha (GP1BA) antagonist. Concentration-dependently inhibits botrocetin-, ristocetin- and low dose thrombin-induced platelet aggregation. Inhibits platelet adhesion only through inhibiting the vWF interaction with GP1BA, but has minimal effect on other platelet receptors, such as alpha-IIb/beta-3 (ITGA2B/ITGB3) or alpha-2/beta-1 (ITGA2/ITGB1). Causes an instant severe thrombocytopenia in rats and is not lethal to mice. Heterodimer of subunits alpha and beta; disulfide-linked.
Also known as SLCA_DEIAC. Is a potent glycoprotein Ibalpha (GP1BA) antagonist. Concentration-dependently inhibits botrocetin-, ristocetin- and low dose thrombin-induced platelet aggregation. Inhibits platelet adhesion only through inhibiting the vWF interaction with GP1BA, but has minimal effect on other platelet receptors, such as alpha-IIb/beta-3 ... More
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Snaclec agkicetin-C subunit alpha

Molecular Synopsis