Fbxo3 logo
Fbxo3 (F-box only protein 3)
FEATURES
Loading...
Loading...
DESCRIPTION
Also known as FBX3_MOUSE, Fbxo3, Fba, Fbx3. Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex (By similarity).
Also known as FBX3_MOUSE, Fbxo3, Fba, Fbx3. Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. P ... More
Fbxo3 logo

Fbxo3

F-box only protein 3

Molecular Synopsis