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Triap1 (TP53-regulated inhibitor of apoptosis 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as TRIA1_MOUSE, Triap1, 15e1.1. Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Monomer. Interacts with APAF1 and HSP70. Forms a complex with PRELID1 in the mitochondrion intermembrane space. Interacts with PRELID3A.
Also known as TRIA1_MOUSE, Triap1, 15e1.1. Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitocho ... More
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Triap1

TP53-regulated inhibitor of apoptosis 1

Molecular Synopsis