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Dennd10 (DENN domain-containing protein 10)
FEATURES
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FAMILY
DESCRIPTION
Also known as DEN10_MOUSE, Dennd10, Fam45a. Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. Interacts with RAB27A and RAB27B (GDP-bound forms preferentially).
Also known as DEN10_MOUSE, Dennd10, Fam45a. Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RA ... More
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Dennd10

DENN domain-containing protein 10

Molecular Synopsis