FEATURES

FAMILY

DESCRIPTION

Also known as THEM5_MOUSE, Them5, Acot15. Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (By similarity). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271). Homodimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

Them5

Acyl-coenzyme A thioesterase THEM5

ligandability Mutations

Them5

Molecular Synopsis