eme1 (Crossover junction endonuclease eme1)

FEATURES

FAMILY

DESCRIPTION

Also known as EME1_SCHPO, eme1, mms4, slx2. Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). Interacts with mus81.

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EXTERNAL LINKS

eme1

Crossover junction endonuclease eme1

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

eme1

Molecular Synopsis