FTO (Alpha-ketoglutarate-dependent dioxygenase FTO)
FEATURES
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DESCRIPTION
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EXTERNAL LINKS
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Germline Genetics

Summary of germline evidence for FTO and cancer

  • Ensembl Gene ID: ENSG00000140718
  • Ensembl Transcript ID/s: ENST00000431610; ENST00000460382; ENST00000463855; ENST00000471389
  • Entrez Gene ID: 79068
  • HGNC Gene Symbol: FTO

Genome-wide association studies

FTO maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
1049_rs1107599516q12.253855291rs11075995-?0.243E-81.11[1.07-1.15]Breast cancer (estrogen-receptor negative)27117709https://www.ebi.ac.uk/gwas/search?query=rs1107599516:53540000-55500000r2>0.9 (16:53853207-53866609)-
2686_rs1107599516q12.253855291rs11075995-A0.31E-101.09[1.06-1.12]Breast cancer (estrogen-receptor negative)29058716https://www.ebi.ac.uk/gwas/search?query=rs1107599516:53540000-55500000r2>0.9 (16:53853207-53866609)-
2265_rs1107599516q12.253855291rs11075995-A0.31E-101.09[1.06-1.12]Breast cancer (estrogen-receptor negative)29058716https://www.ebi.ac.uk/gwas/search?query=rs1107599516:53540000-55500000r2>0.9 (16:53853207-53866609)-
752_rs1107599516q12.253855291rs11075995-A0.249E-91.03[1.01-1.06] (Oncoarray)Breast cancer29059683https://www.ebi.ac.uk/gwas/search?query=rs1107599516:53540000-55500000r2>0.9 (16:53853207-53866609)-
900_rs1107599516q12.253855291rs11075995-?0.244E-81.11[1.07-1.15]Breast cancer23535733https://www.ebi.ac.uk/gwas/search?query=rs1107599516:53540000-55500000r2>0.9 (16:53853207-53866609)-
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