FEATURES

FAMILY

DESCRIPTION

Also known as KDM5D_HUMAN, KDM5D, HY, HYA, JARID1D, KIAA0234, SMCY. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. Interacts with PCGF6, MSH5, ZMYND8, AR.

Also known as KDM5D_HUMAN, KDM5D, HY, HYA, JARID1D, KIAA0234, SMCY. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Doe ...

EXTERNAL LINKS

KDM5D

Lysine-specific demethylase 5D

KDM5D

Molecular Synopsis