FEATURES

FAMILY

DESCRIPTION

Also known as CLH3_CAEEL, clh-3, clc-3. Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150, PubMed:12163466, PubMed:15684092). Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974). Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells (PubMed:11231150, PubMed:24431435). When active, may prevent tubular formation of the excretory canals (PubMed:18049475). Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling (PubMed:11231150, PubMed:14565992). Inhibited by Zn(2+) and to a lesser extent by Cd(2+)(PubMed:11231150)., Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150). Sensitive to depolarizing conditioning voltages, requires stronger voltages for activation and activation is slower, is inhibited by low concentrations of chloride and is activated by low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974). Isoform a interacts (via RFLI motif) with gck-3 (via C-terminus).

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EXTERNAL LINKS

clh-3

Chloride channel protein clh-3

ligandability Mutations

clh-3

Molecular Synopsis