FEATURES

FAMILY

DESCRIPTION

Also known as NR0B1_PONPY, NR0B1, DAX1. Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).

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EXTERNAL LINKS

NR0B1

Nuclear receptor subfamily 0 group B member 1

ligandability Mutations

NR0B1

Molecular Synopsis