spnN (dTDP-3, 4-didehydro-2, 6-dideoxy-alpha-D-glucose 3-reductase)

FEATURES

FAMILY

DESCRIPTION

Also known as SPNN_SACSN, spnN. Involved in the biosynthesis of forosamine ((4-dimethylamino)-2, 3, 4, 6-tetradeoxy-alpha-D-threo-hexopyranose), a highly deoxygenated sugar component of several bioactive natural products such as the insecticidal spinosyns A and D (PubMed:11358695, PubMed:18345667). Catalyzes the reduction of the C-3 keto moiety of dTDP-3, 4-diketo-2, 6-dideoxy-alpha-D-glucose to yield dTDP-4-keto-2, 6-dideoxy-alpha-D-glucose (PubMed:18345667). NADPH is the better reductant, however NADH can also be used (PubMed:18345667). Monomer.

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EXTERNAL LINKS

spnN

dTDP-3, 4-didehydro-2, 6-dideoxy-alpha-D-glucose 3-reductase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

spnN

Molecular Synopsis