FEATURES

FAMILY

DESCRIPTION

Also known as PMYT1_HUMAN, PKMYT1, MYT1. Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.

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EXTERNAL LINKS

PKMYT1

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

ligandability Mutations

PKMYT1

Molecular Synopsis