FEATURES

DESCRIPTION

Also known as CYH2_HUMAN, CYTH2, ARNO, PSCD2, PSCD2L. Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1 (By similarity). Interacts with ARRB1 (PubMed:17623778, PubMed:17398095). Interacts with ARL4D; the interaction is direct (PubMed:17398095). Directly interacts with CCDC120 through the coiled coil domain; this interaction stabilizes CCDC120, possibly by preventing its ubiquitination, and is required for neurite growth in neuroblastoma cells (PubMed:25326380). Interacts with ARF1 (PubMed:14654833). Interacts with FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N-terminal domain) (PubMed:29420262).

Also known as CYH2_HUMAN, CYTH2, ARNO, PSCD2, PSCD2L. Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors throug ...

EXTERNAL LINKS

CYTH2

Cytohesin-2

CYTH2

Molecular Synopsis