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RPRD1A (Regulation of nuclear pre-mRNA domain-containing protein 1A)
FEATURES
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FAMILY
DESCRIPTION
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1B (PubMed:24997600). Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats) (PubMed:22231121, PubMed:24997600, PubMed:24399136).
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1 ...
RPRD1A logo

RPRD1A

Regulation of nuclear pre-mRNA domain-containing protein 1A

Germline Genetics

Summary of germline evidence for RPRD1A and cancer

  • Ensembl Gene ID: ENSG00000141425
  • Ensembl Transcript ID/s: ENST00000357384; ENST00000399022; ENST00000588737; ENST00000590898
  • Entrez Gene ID: 55197
  • HGNC Gene Symbol: RPRD1A

Genome-wide association studies

RPRD1A maps to cancer-SNP associations according to the following annotations:

SNPLocusPosition (b37)Risk alleleRAFP-valueEffect sizeCICancerPMIDCatalogTADLSDEPICT
923_rs1050631 18q12.2 33694120 rs1050631-T 0.18 4E-8 1.3 [1.19-1.43] Esophageal squamous cell cancer (length of survival) 23644492 https://www.ebi.ac.uk/gwas/search?query=rs1050631 18:32900000-34420000 r2>0.2 (18:33426388-33793895) -