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RPRD1A (Regulation of nuclear pre-mRNA domain-containing protein 1A)
FEATURES
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FAMILY
DESCRIPTION
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1B (PubMed:24997600). Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats) (PubMed:22231121, PubMed:24997600, PubMed:24399136).
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1 ...
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RPRD1A

Regulation of nuclear pre-mRNA domain-containing protein 1A

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.27 2.09 1.97 1.88 1.56 126 2.28 2.07 2.03 1.99 -0.09 -0.07
Bladder (BLCA) 406 2.37 2.01 1.92 1.81 1.46 9 2.24 2.15 2.11 1.91 1.88 -0.19
Breast (BRCA) 1067 2.54 2.06 1.96 1.86 1.42 178 2.12 1.95 1.91 1.88 1.72 0.05
Cervical (CESC) 297 2.22 2.01 1.94 1.87 1.55 10 2.07 2.07 1.99 1.93 1.88 -0.04
Cholangiocarcinoma (CHOL) 36 2.58 2.15 2.02 1.91 1.68 0
Colon (COAD) 443 2.68 2.01 1.91 1.81 1.46 166 2.18 1.99 1.85 1.79 -0.09 0.06
B-cell lymphoma (DLBC) 42 2.16 1.92 1.81 1.74 1.46 337 2.15 1.87 1.81 1.71 1.18 0.00
Esophageal (ESCA) 142 2.39 2.03 1.92 1.80 1.61 271 2.10 1.93 1.89 1.85 -0.09 0.03
Glioblastoma (GBM) 160 2.46 2.12 2.05 1.99 1.78 214 2.35 2.14 2.10 2.06 -0.09 -0.04
Head and neck (HNSC) 432 2.35 1.99 1.89 1.80 1.45 55 2.05 1.94 1.92 1.88 1.81 -0.02