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RPRD1A (Regulation of nuclear pre-mRNA domain-containing protein 1A)
FEATURES
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FAMILY
DESCRIPTION
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1B (PubMed:24997600). Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats) (PubMed:22231121, PubMed:24997600, PubMed:24399136).
Also known as RPR1A_HUMAN, RPRD1A, P15RS. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1 ...
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RPRD1A

Regulation of nuclear pre-mRNA domain-containing protein 1A

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 5 1 1.88 4 0.46 142 0.85
NS 7 3 2.49 4 0.44 146 0.83
carcinoma 14 5 2.33 9 0.43 538 0.88
haematopoietic_neoplasm 0 0 0 63 0.98
leukaemia 0 0 0 84 1.01
lymphoid_neoplasm 0 0 0 135 1.02
glioma 0 0 0 52 0.93
malignant_melanoma 0 0 0 56 0.94
melanoma 0 0 0 43 0.92
glioblastoma 0 0 0 2 1.11

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 3 2.41 1.25 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 4 3.09 1.29 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid