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PBK (Lymphokine-activated killer T-cell-originated protein kinase)
FEATURES
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FAMILY
DESCRIPTION
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
PBK logo

PBK

Lymphokine-activated killer T-cell-originated protein kinase

Mutations

FILTERS

Mutation(s) distribution

Mutations table

Study NameMutation TypeSeveritySeq. Cons. ScorePrediction scorePositionAmino acid changeTCGA Patient ID
Bladder (BLCA) Missense variant MODERATE 0% 0% 321 Asp321Asn TCGA-GC-A3OO
Melanoma (SKCM) Missense variant MODERATE 0% 0% 319 Glu319Lys TCGA-EB-A3XF
Ovarian (OV) Missense variant MODERATE 0% 0% 311 Ala311Val TCGA-29-1764
Uterine endometrial (UCEC) Missense variant MODERATE 0% 0% 308 Arg308Cys TCGA-AX-A2HC
Liver (LIHC) Missense variant MODERATE 0% 0% 303 Glu303Val TCGA-4R-AA8I
Uterine endometrial (UCEC) Missense variant MODERATE 0% 0% 298 Ser298Tyr TCGA-AP-A1DV
Breast (BRCA) Stop gained HIGH 0% 0% 295 Glu295* TCGA-AN-A046
Glioblastoma (GBM) Missense variant MODERATE 0% 0% 291 Gln291Lys TCGA-06-5416
Ovarian (OV) Missense variant MODERATE 0% 0% 285 Glu285Lys TCGA-24-1422
Uterine endometrial (UCEC) Missense variant MODERATE 0% 0% 260 Thr260Pro TCGA-E6-A1LX