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PBK (Lymphokine-activated killer T-cell-originated protein kinase)
FEATURES
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FAMILY
DESCRIPTION
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
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PBK

Lymphokine-activated killer T-cell-originated protein kinase

Expression

StudyTumor samplesMaxQ3Q2Q1MinNormal samplesMaxQ3Q2Q1MinLog2 (T vs N)
Adrenocortical (ACC) 77 2.38 1.74 1.45 0.99 0.25 126 1.75 0.64 0.29 0.01 -0.03 1.16
Bladder (BLCA) 406 2.18 1.61 1.43 1.26 0.25 9 0.82 0.59 -0.47 -0.10 -0.01 1.90
Breast (BRCA) 1067 2.06 1.57 1.39 1.17 0.06 178 1.22 0.11 -0.47 -0.18 -0.00 1.85
Cervical (CESC) 297 2.19 1.77 1.67 1.54 1.16 10 1.38 0.67 0.16 -0.34 -0.23 1.50
Cholangiocarcinoma (CHOL) 36 1.87 1.35 1.13 0.95 0.38 0
Colon (COAD) 443 2.45 1.80 1.62 1.43 0.25 166 1.75 1.17 0.88 0.18 -0.01 0.74
B-cell lymphoma (DLBC) 42 2.04 1.84 1.69 1.49 1.16 337 1.61 0.45 0.12 -0.33 -0.00 1.57
Esophageal (ESCA) 142 2.17 1.67 1.55 1.40 0.94 271 1.83 1.39 1.26 1.13 -0.09 0.30
Glioblastoma (GBM) 160 2.15 1.76 1.60 1.44 0.49 214 0.47 -0.72 -0.69 -0.40 -0.03 2.29
Head and neck (HNSC) 432 2.39 1.66 1.52 1.35 0.73 55 1.50 0.77 0.31 -0.47 -0.03 1.21