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PBK (Lymphokine-activated killer T-cell-originated protein kinase)
FEATURES
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FAMILY
DESCRIPTION
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
PBK logo

PBK

Lymphokine-activated killer T-cell-originated protein kinase

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 5 0 5 0.40 142 0.81
NS 6 0 6 0.38 147 0.83
carcinoma 8 0 8 0.38 544 0.85
haematopoietic_neoplasm 0 0 0 63 1.13
leukaemia 0 0 0 84 1.12
lymphoid_neoplasm 1 0 1 0.43 134 0.99
glioma 0 0 0 52 1.00
malignant_melanoma 0 0 0 56 0.93
melanoma 0 0 0 43 0.94
glioblastoma 0 0 0 2 1.11

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 3 2.04 1.47 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 2 3.82 0.52 cancer, carcinoma kidney
8-MG-BA No signal 1 2.20 0.46 glioma brain, central_nervous_system
8305C No signal 2 3.09 0.65 carcinoma thyroid
8505C No signal 2 3.00 0.67 carcinoma thyroid