FEATURES

FAMILY

alpha-ketoglutarate dehydrogenase family

DESCRIPTION

Also known as ODO1_STAAM, odhA. E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

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EXTERNAL LINKS

odhA

2-oxoglutarate dehydrogenase E1 component

ligandability Mutations

odhA

Molecular Synopsis